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SCHIZOPHRENIA UNRESPONSIVE TO ANTIPSYCHOTIC DRUGS

Patients with schizophrenia who fail to respond to antipsychotic medications may have something in common — they appear to have normal levels of the neurotransmitter dopamine.Schizophrenia is typically associated with an overactive dopamine system, which means that the brain is processing abnormally high levels of dopamine. However, about one-third of individuals with schizophrenia do not respond to this treatment, and until now, no study has focused on whether dopamine abnormality is present in patients resistant to antipsychotic treatment.  Source:  American Journal of Psychiatry.

http://psychcentral.com/news/2012/12/03/why-some-schizophrenia-patients-are-unresponsive-to-antipsychotic-drug

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